Effect of training and recovery on airway inflammation in an animal model of ‚ski asthma╎
نویسندگان
چکیده
Repeated strenuous exercise while breathing cold air is believed to induce chronic airway inflammation and hyperreactivity, a condition referred to in humans as ‘ski asthma’. However, the time course of development and resolution of ski asthma is unknown. We have previously shown that multi-day aerobic exercise induces airway inflammation and hyperreactivity in racing sled dogs. In the present study, a similar group of subjects was examined at multiple times during training to test the hypothesis that ski asthma spontaneously resolves during seasonal detraining, but is re-induced during training in the cold weather. At the beginning of training, bronchoalveolar lavage fluid (BALF) from detrained elite sled dogs (n 1⁄4 16) had higher concentrations of lymphocytes (median 53.63 vs. 8.30 cellsml) and neutrophils (median 23.03 vs. 1.10 cellsml) compared with normal laboratory dogs (n 1⁄4 5). However, there was no significant effect of training on BALF nucleated cell concentrations from exercised sled dogs (n 1⁄4 11) compared with sedentary sled dogs (n 1⁄4 8). In contrast to our hypothesis, our data support the contention that cold weather exercise-induced airway inflammation can persist through seasonal detraining, but that routine training does not cause significant worsening of the condition.
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